Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:activities |
inhibits folate metabolism
|
| gptkbp:appointed_by |
vitamin B12
folic acid intravenous injection |
| gptkbp:approves |
gptkb:2004
gptkb:FDA |
| gptkbp:availability |
prescription only
|
| gptkbp:clinical_trial |
Phase II
Phase III |
| gptkbp:contraindication |
severe renal impairment
hypersensitivity to pemetrexed |
| gptkbp:discovered_by |
gptkb:Eli_Lilly_and_Company
|
| gptkbp:dosage_form |
based on renal function
|
| gptkbp:excretion |
urine
|
| gptkbp:formulation |
lyophilized powder for injection
|
| gptkbp:frequency |
every 21 days
|
| https://www.w3.org/2000/01/rdf-schema#label |
pemetrexed
|
| gptkbp:indication |
gptkb:malignant_pleural_mesothelioma
non-squamous non-small cell lung cancer |
| gptkbp:ingredients |
C20 H22 N8 O6 S
|
| gptkbp:interacts_with |
other chemotherapy agents
NSAI Ds |
| gptkbp:invention |
patented
generic available |
| gptkbp:is_atype_of |
L01 B A04
|
| gptkbp:is_used_for |
treatment of non-small cell lung cancer
treatment of malignant pleural mesothelioma |
| gptkbp:lifespan |
3 to 6 hours
|
| gptkbp:marketed_as |
gptkb:Alimta
|
| gptkbp:metabolism |
minimal hepatic metabolism
|
| gptkbp:pharmacokinetics |
gptkb:fragrance
dose-dependent clearance |
| gptkbp:population |
adults
elderly |
| gptkbp:price |
high
|
| gptkbp:provides_information_on |
combination therapy
ASCO guidelines NCCN guidelines single-agent therapy |
| gptkbp:research |
ongoing clinical trials
retrospective studies prospective studies |
| gptkbp:research_focus |
biomarker identification
resistance mechanisms combination with immunotherapy |
| gptkbp:safety_features |
liver function tests
complete blood count renal function tests |
| gptkbp:scholarships |
gptkb:Educational_Institution
financial assistance programs |
| gptkbp:side_effect |
gptkb:fandom
fatigue nausea neutropenia |
| gptkbp:storage |
room temperature
|
| gptkbp:treatment |
symptom relief
improved survival rates |
| gptkbp:type_of |
137281-23-3
|
| gptkbp:bfsParent |
gptkb:Alimta
|
| gptkbp:bfsLayer |
4
|