pegylated interferon alpha

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:drug gptkb:biologic_therapy
gptkbp:approvedBy	gptkb:FDA gptkb:EMA 2001
gptkbp:ATCCode	L03AB11
gptkbp:brand	gptkb:PegIntron gptkb:Pegasys
gptkbp:CASNumber	198153-51-4
gptkbp:combines	direct-acting antivirals ribavirin
gptkbp:contraindication	autoimmune hepatitis decompensated liver disease severe psychiatric disorders
gptkbp:developedBy	gptkb:Schering-Plough gptkb:Roche
gptkbp:discoveredIn	1990s
gptkbp:eliminationHalfLife	about 50-80 hours
gptkbp:form	solution for injection
gptkbp:halfLife	longer than conventional interferon alpha
gptkbp:hasComponent	gptkb:interferon_alpha
gptkbp:hasModification	gptkb:plastic
gptkbp:KEGGID	D08144
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	immunomodulation antiviral activity
gptkbp:MedlinePlusID	a605018
gptkbp:metabolism	renal hepatic
gptkbp:pregnancyCategory	C
gptkbp:PubChem_CID	gptkb:CHEMBL1201562 16129680 DB00008
gptkbp:replacedBy	direct-acting antivirals
gptkbp:routeOfAdministration	subcutaneous injection
gptkbp:sideEffect	gptkb:depression gptkb:anemia neutropenia thrombocytopenia flu-like symptoms
gptkbp:UNII	J4N7LZ7Z1E
gptkbp:usedFor	gptkb:hepatitis_C gptkb:hepatitis_B
gptkbp:WHOModelListOfEssentialMedicines	yes
gptkbp:bfsParent	gptkb:Hepatitis_D_virus
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	pegylated interferon alpha