Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:cofactor |
gptkb:S-adenosylmethionine
zinc |
| gptkbp:encodedBy |
orf1ab polyprotein
|
| gptkbp:Entrez_Gene_ID |
43740578 (SARS-CoV-2)
|
| gptkbp:foundIn |
coronaviruses
|
| gptkbp:fullName |
non-structural protein 14
|
| gptkbp:function |
exoribonuclease activity
N7-methyltransferase activity |
| https://www.w3.org/2000/01/rdf-schema#label |
nsp14
|
| gptkbp:inhibitedBy |
Sinefungin
|
| gptkbp:interactsWith |
gptkb:nsp10
|
| gptkbp:length |
527 amino acids (SARS-CoV-2)
|
| gptkbp:mutationAssociatedWith |
increased sensitivity to mutagens
reduced viral replication fidelity |
| gptkbp:PDB |
7DIY
7EGQ 7N0B |
| gptkbp:presentIn |
gptkb:COVID-19
gptkb:MERS-CoV gptkb:SARS-CoV gptkb:other_betacoronaviruses |
| gptkbp:requires |
coronavirus replication
|
| gptkbp:role |
viral RNA proofreading
viral mRNA capping |
| gptkbp:structure |
two domains: ExoN and N7-MTase
|
| gptkbp:bfsParent |
gptkb:SARS-CoV-2_virion
|
| gptkbp:bfsLayer |
7
|