metformin hydrochloride extended-release

URI: https://gptkb.org/entity/metformin_hydrochloride_extended-release
GPTKB entity
Statements (28)
Predicate Object
gptkbp:instanceOf gptkb:drug
oral antidiabetic agent
gptkbp:activeIngredient metformin hydrochloride
gptkbp:approvalYear 1995 (US, for metformin XR)
gptkbp:ATCCode A10BA02
gptkbp:brand gptkb:Glucophage_XR
gptkb:Fortamet
gptkb:Glumetza
gptkbp:chemicalClass biguanide
gptkbp:contraindication severe renal impairment
metabolic acidosis
gptkbp:developer Bristol-Myers Squibb (original metformin)
gptkbp:eliminationHalfLife 6.2 hours (extended-release)
gptkbp:excretion renal
gptkbp:form extended-release tablet
https://www.w3.org/2000/01/rdf-schema#label metformin hydrochloride extended-release
gptkbp:indication gptkb:type_2_diabetes_mellitus
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction increases insulin sensitivity
reduces hepatic glucose production
gptkbp:metabolism not metabolized
gptkbp:pregnancyCategory B (US)
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gastrointestinal upset
lactic acidosis (rare)
gptkbp:bfsParent gptkb:Glucophage_XR
gptkb:Glumetza_XR
gptkbp:bfsLayer 7