|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:affiliatedWith
|
gptkb:class_II_aminoacyl-tRNA_synthetase
|
|
gptkbp:alternativeName
|
gptkb:KARS
LysRS
Lysine--tRNA ligase
|
|
gptkbp:associatedWith
|
gptkb:Charcot-Marie-Tooth_disease
Deafness, autosomal recessive 89
|
|
gptkbp:biologicalProcess
|
translator
ATP binding
amino acid activation
aminoacyl-tRNA biosynthesis
lysine-tRNA ligase activity
tRNA binding
|
|
gptkbp:catalyzes
|
ATP + L-lysine + tRNA(Lys) → AMP + diphosphate + L-lysyl-tRNA(Lys)
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:EC_number
|
6.1.1.6
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000165060
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:function
|
aminoacylation of tRNA(Lys)
|
|
gptkbp:gene
|
gptkb:KARS
KARS1
KARS2
|
|
gptkbp:GO_term
|
GO:0004825
|
|
gptkbp:HGNC_ID
|
HGNC:6217
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
lysyl-tRNA synthetase
|
|
gptkbp:inhibitedBy
|
cladosporin
|
|
gptkbp:locatedOnChromosome
|
16q23.1
|
|
gptkbp:location
|
gptkb:cytoplasm
mitochondrion
|
|
gptkbp:OMIM
|
601421
|
|
gptkbp:organism
|
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
gptkb:Bacteria
|
|
gptkbp:orthologIn
|
mouse Kars
yeast KRS1
|
|
gptkbp:participatedIn
|
protein biosynthesis
|
|
gptkbp:PDB
|
1B8A
2ZT5
|
|
gptkbp:product
|
gptkb:AMP
diphosphate
L-lysyl-tRNA(Lys)
|
|
gptkbp:RefSeq
|
NP_005539.1
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:ATP
L-lysine
tRNA(Lys)
|
|
gptkbp:UniProtID
|
gptkb:P49588
|
|
gptkbp:bfsParent
|
gptkb:class_II_aminoacyl-tRNA_synthetase
|
|
gptkbp:bfsLayer
|
7
|