immunoreceptor tyrosine-based activation motif (ITAM)

GPTKB entity

Statements (18)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:ITAM
gptkbp:discoveredBy Ravetch and colleagues
gptkbp:firstDescribed 1991
gptkbp:foundIn immunoreceptor cytoplasmic domains
gptkbp:function signal transduction
https://www.w3.org/2000/01/rdf-schema#label immunoreceptor tyrosine-based activation motif (ITAM)
gptkbp:motif YxxL/Ix(6-8)YxxL/I
gptkbp:phosphorylates gptkb:protein_tyrosine_kinases
gptkbp:presentIn Dectin-1
CD3 chains
Fc receptor gamma chain
gptkbp:recruitedFrom Syk family kinases
gptkbp:role B cell receptor signaling
immune cell activation
T cell receptor signaling
gptkbp:bfsParent gptkb:K1_protein
gptkbp:bfsLayer 7