Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:conservedIn |
gptkb:metazoans
|
| gptkbp:contains |
gptkb:HOXA_cluster
homeobox domain HOXB cluster HOXC cluster HOXD cluster |
| gptkbp:discoveredBy |
gptkb:Edward_B._Lewis
|
| gptkbp:encodes |
transcription factors
|
| gptkbp:evolvesFrom |
bilaterian ancestor
|
| gptkbp:expressedIn |
embryogenesis
|
| gptkbp:firstDescribed |
1983
|
| gptkbp:foundIn |
animals
invertebrates vertebrates |
| gptkbp:function |
regulation of embryonic development
anterior-posterior patterning |
| https://www.w3.org/2000/01/rdf-schema#label |
homeobox (HOX) gene family
|
| gptkbp:locatedOnChromosome |
chromosome 12 (HOXC)
chromosome 17 (HOXB) chromosome 2 (HOXD) chromosome 7 (HOXA) |
| gptkbp:motif |
homeodomain
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
congenital malformations homeotic transformation limb malformations |
| gptkbp:numberOfGenes |
39 (in humans)
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens gptkb:Drosophila_melanogaster |
| gptkbp:regulates |
cell differentiation
morphogenesis organogenesis segment identity body plan specification |
| gptkbp:regulatoryElement |
promoter
enhancer |
| gptkbp:relatedTo |
homeobox genes
NK gene cluster ParaHox gene cluster ANTP-class homeobox genes Hox code |
| gptkbp:studiedIn |
developmental biology
evolutionary biology genetics molecular biology |
| gptkbp:bfsParent |
gptkb:HOXA9
|
| gptkbp:bfsLayer |
7
|