Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeIn |
humans
other mammals |
| gptkbp:alternativeName |
gptkb:beta-N-acetylhexosaminidase_A
|
| gptkbp:associatedWith |
gptkb:Sandhoff_disease
|
| gptkbp:biologicalProcess |
hydrolase activity
|
| gptkbp:catalyzes |
hydrolysis of terminal N-acetyl-D-hexosamine residues
|
| gptkbp:composedOf |
alpha subunit
beta subunit |
| gptkbp:deficiencyCauses |
gptkb:Tay–Sachs_disease
|
| gptkbp:EC_number |
3.2.1.52
|
| gptkbp:encodedBy |
gptkb:HEXA_gene
|
| gptkbp:foundIn |
gptkb:lysosome
|
| https://www.w3.org/2000/01/rdf-schema#label |
hexosaminidase A
|
| gptkbp:involves |
degradation of GM2 gangliosides
glycosphingolipid metabolism |
| gptkbp:location |
gptkb:chromosome_15_(HEXA_gene)
|
| gptkbp:OMIM |
606869
|
| gptkbp:structure |
heterodimer
|
| gptkbp:substrate |
gptkb:GM2_ganglioside
|
| gptkbp:UniProtID |
P06865
|
| gptkbp:bfsParent |
gptkb:Tay-Sachs_disease
|
| gptkbp:bfsLayer |
5
|