|
gptkbp:instanceOf
|
ganglioside
|
|
gptkbp:abnormal_accumulation_causes
|
neurodegeneration
|
|
gptkbp:accumulates_in
|
gptkb:Sandhoff_disease
gptkb:Tay-Sachs_disease
|
|
gptkbp:biosynthesized_from
|
gptkb:GM3_ganglioside
|
|
gptkbp:chemicalFormula
|
C77H138N3O31
|
|
gptkbp:class
|
glycosphingolipid
|
|
gptkbp:component
|
neuronal cell membranes
|
|
gptkbp:contains
|
gptkb:N-acetylgalactosamine
glucose
galactose
ceramide
sialic acid
|
|
gptkbp:degradedBy
|
gptkb:GM3_ganglioside
gptkb:beta-hexosaminidase_A
|
|
gptkbp:foundIn
|
human nervous system
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GM2 ganglioside
|
|
gptkbp:IUPACName
|
gptkb:N-acetyl-beta-D-galactosaminyl-(1→4)-[N-acetyl-alpha-neuraminosyl-(2→3)]-beta-D-galactosyl-(1→4)-beta-D-glucosyl-(1→1)-ceramide
|
|
gptkbp:mutationAssociatedWith
|
GM2A gene affects degradation
HEXA gene affects degradation
HEXB gene affects degradation
|
|
gptkbp:namedAfter
|
ganglion cells
|
|
gptkbp:predecessor
|
gptkb:GM3_ganglioside
|
|
gptkbp:relatedTo
|
gptkb:GM1_ganglioside
gptkb:GM3_ganglioside
GM4 ganglioside
|
|
gptkbp:role
|
cell signaling
cell adhesion
cell recognition
|
|
gptkbp:bfsParent
|
gptkb:GM2_gangliosidosis,_type_I
gptkb:hexosaminidase_A
|
|
gptkbp:bfsLayer
|
6
|