hepatic triglyceride lipase

URI: https://gptkb.org/entity/hepatic_triglyceride_lipase
GPTKB entity
Statements (30)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs gptkb:LIPC
HTGL
gptkbp:cofactor requires heparin for binding to endothelium
gptkbp:deficiencyCauses familial hepatic lipase deficiency
gptkbp:EC_number 3.1.1.3
gptkbp:encodedBy LIPC gene
gptkbp:function hydrolyzes triglycerides in lipoproteins
hydrolyzes phospholipids in lipoproteins
gptkbp:GO_term GO:0003841
https://www.w3.org/2000/01/rdf-schema#label hepatic triglyceride lipase
gptkbp:locatedOnChromosome gptkb:chromosome_15q21-q23_(human)
gptkbp:location liver
endothelial cells of hepatic sinusoids
gptkbp:molecularWeight about 55 kDa
gptkbp:OMIM 151670
gptkbp:participatedIn lipid metabolism
reverse cholesterol transport
gptkbp:regulates regulated by androgens
regulated by estrogens
regulated by insulin
gptkbp:species gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:structure gptkb:protein
gptkbp:substrate gptkb:intermediate-density_lipoprotein
high-density lipoprotein
chylomicron remnants
gptkbp:UniProtID P11150
gptkbp:bfsParent gptkb:LIPC
gptkbp:bfsLayer 8