Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
hemoglobin
|
| gptkbp:affects |
red blood cells
|
| gptkbp:alsoKnownAs |
gptkb:HbS
|
| gptkbp:aminoAcidChange |
glutamic acid to valine at position 6 of beta-globin chain
|
| gptkbp:associatedWith |
gptkb:anemia
painful vaso-occlusive crises |
| gptkbp:cause |
sickle cell disease
sickling of red blood cells |
| gptkbp:diagnosedBy |
hemoglobin electrophoresis
|
| gptkbp:discoveredBy |
gptkb:James_V._Neel
|
| gptkbp:discoveredIn |
1949
|
| gptkbp:encodedBy |
gptkb:HBB_gene
|
| gptkbp:form |
fibers under low oxygen conditions
|
| gptkbp:foundIn |
humans
|
| https://www.w3.org/2000/01/rdf-schema#label |
hemoglobin S
|
| gptkbp:inheritance |
autosomal recessive
|
| gptkbp:molecularWeight |
approximately 64,500 Da
|
| gptkbp:mutationAssociatedWith |
gptkb:hemoglobin_A
|
| gptkbp:prevalence |
people of African descent
|
| gptkbp:resistantTo |
malaria
|
| gptkbp:treatment |
gptkb:hydroxyurea
blood transfusions bone marrow transplant |
| gptkbp:bfsParent |
gptkb:hemoglobin
|
| gptkbp:bfsLayer |
5
|