Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Cell
|
| gptkbp:application |
used in cancer treatment
|
| gptkbp:cell_fate |
influence cell fate decisions in hematopoiesis
|
| gptkbp:cell_signaling |
involved in various cell signaling pathways
|
| gptkbp:cell_therapy |
used in cell therapy approaches
|
| gptkbp:cell_types |
differentiate into various cell types in the blood
|
| gptkbp:cellular_interactions |
involved in cellular interactions within the bone marrow
|
| gptkbp:characteristic |
self-renewing
|
| gptkbp:characterized_by |
characterized by flow cytometry
|
| gptkbp:clinical_trial |
play a significant role in hematopoiesis
subject of numerous clinical trials for therapies |
| gptkbp:clinical_use |
have various clinical applications in medicine
used in bone marrow transplants |
| gptkbp:descendant |
give rise to erythrocytes, leukocytes, and platelets
|
| gptkbp:differentiation |
can differentiate into myeloid and lymphoid lineages
|
| gptkbp:diseases |
associated with various hematological diseases
|
| gptkbp:ecological_role |
essential for maintaining blood homeostasis
|
| gptkbp:expansion |
can be expanded ex vivo for therapeutic use
|
| gptkbp:financial_stability |
maintain genomic stability during division
|
| gptkbp:function |
give rise to all blood cell types
|
| gptkbp:future_prospects |
have potential for gene therapy applications
|
| https://www.w3.org/2000/01/rdf-schema#label |
hematopoietic stem cells
|
| gptkbp:importance |
critical for blood formation
|
| gptkbp:isolation |
can be isolated from peripheral blood
|
| gptkbp:lifespan |
have a long lifespan in the body
|
| gptkbp:location |
bone marrow
|
| gptkbp:marker |
CD34 positive
|
| gptkbp:markers |
express various surface markers
|
| gptkbp:microenvironment |
influenced by the bone marrow niche
|
| gptkbp:migration |
can migrate to sites of injury
|
| gptkbp:origin |
originate from the mesoderm during embryonic development
|
| gptkbp:proliferation |
can proliferate in vitro
|
| gptkbp:regulatory_compliance |
regulated by various growth factors
|
| gptkbp:research |
studied for regenerative medicine
|
| gptkbp:research_areas |
used in treating leukemia and lymphoma
have therapeutic potential in regenerative medicine |
| gptkbp:research_focus |
focus of research in stem cell biology
|
| gptkbp:role |
in immune system development
|
| gptkbp:source |
can be derived from umbilical cord blood
|
| gptkbp:stem_cell_niche |
reside in a specialized stem cell niche in the bone marrow
|
| gptkbp:therapeutic_strategies |
targeted in various therapeutic strategies
|
| gptkbp:therapy |
used in treating blood disorders
|
| gptkbp:transcription_factors |
regulated by specific transcription factors
|
| gptkbp:transcriptional_regulation |
involved in transcriptional regulation of hematopoiesis
|
| gptkbp:transplantation |
can be transplanted to restore blood cell production
|
| gptkbp:treatment |
impact clinical outcomes in transplantation
|
| gptkbp:type |
adult stem cells
|
| gptkbp:type_of |
include long-term and short-term repopulating stem cells
|
| gptkbp:bfsParent |
gptkb:NOTCH1
gptkb:Philadelphia_chromosome gptkb:David_Scadden gptkb:BCR-ABL_fusion_gene |
| gptkbp:bfsLayer |
5
|