glyceraldehyde-3-phosphate dehydrogenase

URI: https://gptkb.org/entity/glyceraldehyde-3-phosphate_dehydrogenase
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:GAPDH
gptkb:phosphoglyceraldehyde_dehydrogenase
gptkb:triosephosphate_dehydrogenase
gptkbp:associatedWith gptkb:Alzheimer's_disease
apoptosis
gptkbp:biologicalProcess oxidoreductase activity
gptkbp:catalyzes conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate
gptkbp:cofactor NAD+
gptkbp:EC_number 1.2.1.12
gptkbp:expressedIn all tissues
gptkbp:firstDescribed 1930s
gptkbp:foundIn gptkb:Bacteria
archaea
eukaryotes
gptkbp:gene gptkb:GAPDH
gptkbp:gene_location_(human) gptkb:chromosome_12p13.31
gptkbp:GO_term GO:0004365
https://www.w3.org/2000/01/rdf-schema#label glyceraldehyde-3-phosphate dehydrogenase
gptkbp:inhibitedBy arsenate
iodoacetate
gptkbp:involves DNA repair
neurodegeneration
energy metabolism
RNA binding
oxidative stress response
transcription regulation
membrane fusion
spermatogenesis
apoptosis signaling
microtubule bundling
nuclear functions
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight ~36 kDa
gptkbp:pathway glycolysis
gptkbp:PDB_ID_(human) 1U8F
gptkbp:product gptkb:H+
gptkb:NADH
phosphate
1,3-bisphosphoglycerate
gptkbp:regulates post-translational modifications
gptkbp:structure X-ray crystallography
gptkbp:substrate glyceraldehyde-3-phosphate
gptkbp:subunit tetramer
gptkbp:UniProtID P04406
gptkbp:usedFor housekeeping gene in qPCR
gptkbp:bfsParent gptkb:Calvin_cycle
gptkbp:bfsLayer 6