Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
GS
glutamate-ammonia ligase |
| gptkbp:catalyzes |
synthesis of glutamine from glutamate and ammonia
|
| gptkbp:cofactor |
gptkb:ATP
|
| gptkbp:discoveredBy |
gptkb:David_M._Stadtman
|
| gptkbp:discoveredIn |
1950s
|
| gptkbp:EC_number |
6.3.1.2
|
| gptkbp:encodedBy |
GLUL gene (in humans)
|
| gptkbp:expressedIn |
astrocytes (in brain)
|
| gptkbp:foundIn |
gptkb:Bacteria
animals humans plants |
| gptkbp:GO_term |
glutamine biosynthetic process
|
| gptkbp:inhibitedBy |
methionine sulfoximine
|
| gptkbp:involves |
nitrogen metabolism
amino acid biosynthesis |
| gptkbp:locatedIn |
gptkb:cytoplasm
|
| gptkbp:PDB |
2OJW
|
| gptkbp:product |
gptkb:ADP
phosphate L-glutamine |
| gptkbp:regulates |
allosteric regulation
covalent modification (adenylylation in bacteria) |
| gptkbp:requires |
detoxification of ammonia
neurotransmitter cycling in brain |
| gptkbp:structure |
multimeric (often dodecameric)
|
| gptkbp:substrate |
gptkb:L-glutamate
ammonia |
| gptkbp:UniProtID |
P15104 (human)
|
| gptkbp:bfsParent |
gptkb:L-glutamate
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
glutamine synthetase
|