|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
GS
glutamate-ammonia ligase
|
|
gptkbp:catalyzes
|
synthesis of glutamine from glutamate and ammonia
|
|
gptkbp:cofactor
|
gptkb:ATP
|
|
gptkbp:discoveredBy
|
gptkb:David_M._Stadtman
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:EC_number
|
6.3.1.2
|
|
gptkbp:encodedBy
|
GLUL gene (in humans)
|
|
gptkbp:expressedIn
|
astrocytes (in brain)
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
humans
plants
|
|
gptkbp:GO_term
|
glutamine biosynthetic process
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glutamine synthetase
|
|
gptkbp:inhibitedBy
|
methionine sulfoximine
|
|
gptkbp:involves
|
nitrogen metabolism
amino acid biosynthesis
|
|
gptkbp:locatedIn
|
gptkb:cytoplasm
|
|
gptkbp:PDB
|
2OJW
|
|
gptkbp:product
|
gptkb:ADP
phosphate
L-glutamine
|
|
gptkbp:regulates
|
allosteric regulation
covalent modification (adenylylation in bacteria)
|
|
gptkbp:requires
|
detoxification of ammonia
neurotransmitter cycling in brain
|
|
gptkbp:structure
|
multimeric (often dodecameric)
|
|
gptkbp:substrate
|
gptkb:L-glutamate
ammonia
|
|
gptkbp:UniProtID
|
P15104 (human)
|
|
gptkbp:bfsParent
|
gptkb:L-glutamate
gptkb:CHEBI:15765
gptkb:C00378
|
|
gptkbp:bfsLayer
|
7
|