|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
L-glutaminase
glutaminase I
phosphate-activated glutaminase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:hepatic_encephalopathy
|
|
gptkbp:biologicalProcess
|
glutaminase activity
glutamine catabolic process
|
|
gptkbp:CASNumber
|
9001-47-2
|
|
gptkbp:catalyzes
|
conversion of glutamine to glutamate and ammonia
|
|
gptkbp:cellularComponent
|
mitochondrion
|
|
gptkbp:cofactor
|
none
|
|
gptkbp:EC_number
|
3.5.1.2
|
|
gptkbp:expressedIn
|
neurons
renal tubule cells
|
|
gptkbp:foundIn
|
gptkb:kidney
brain
liver
|
|
gptkbp:gene
|
gptkb:GLS2
gptkb:GLS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glutaminase
|
|
gptkbp:inhibitedBy
|
6-diazo-5-oxo-L-norleucine (DON)
BPTES
|
|
gptkbp:product
|
gptkb:L-glutamate
ammonia
|
|
gptkbp:regulates
|
regulated by pH
activated by phosphate
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:substrate
|
L-glutamine
|
|
gptkbp:UniProtID
|
O43174 (GLS2, human)
O94925 (GLS, human)
|
|
gptkbp:used_in
|
cancer metabolism research
amino acid metabolism studies
|
|
gptkbp:bfsParent
|
gptkb:L-glutamate
gptkb:C00378
|
|
gptkbp:bfsLayer
|
7
|