filgrastim

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkb:granulocyte_colony-stimulating_factor
gptkbp:approvalYear 1991
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode L03AA02
gptkbp:biosimilar yes
gptkbp:brand gptkb:Accofil
gptkb:Grastofil
gptkb:Neupogen
gptkb:Nivestim
gptkb:Zarzio
gptkbp:CASNumber 121181-53-1
gptkbp:contraindication hypersensitivity to filgrastim
gptkbp:developedBy gptkb:Amgen
gptkbp:drugClass colony-stimulating factors
gptkbp:eliminationHalfLife 3.5 hours
gptkbp:firstApprovedCountry gptkb:United_States
gptkbp:hasMolecularFormula C845H1343N223O243S9
https://www.w3.org/2000/01/rdf-schema#label filgrastim
gptkbp:indication chronic neutropenia
mobilization of hematopoietic progenitor cells
myelosuppressive therapy
reduce infection risk in neutropenic patients
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction stimulates production of neutrophils
gptkbp:metabolism renal
gptkbp:origin recombinant DNA technology
gptkbp:orthologIn endogenous human G-CSF
gptkbp:pharmacokinetics linear
gptkbp:pregnancyCategory C (US)
gptkbp:product gptkb:protein
gptkbp:proteinSequence recombinant human G-CSF
gptkbp:routeOfAdministration subcutaneous injection
intravenous injection
gptkbp:sideEffect fever
splenomegaly
bone pain
allergic reactions
injection site reactions
gptkbp:storage refrigerated
gptkbp:UNII 6U8Z86QG6M
gptkbp:usedFor bone marrow transplantation
neutropenia
chemotherapy-induced neutropenia
HIV-associated neutropenia
peripheral blood progenitor cell collection
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Amgen,_Inc.
gptkb:Neulasta
gptkbp:bfsLayer 7