granulocyte colony-stimulating factor
GPTKB entity
Statements (46)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cytokine |
| gptkbp:abbreviation |
G-CSF
|
| gptkbp:CASNumber |
121181-53-1
|
| gptkbp:category |
immunology
oncology hematology |
| gptkbp:discoveredBy |
Shigetada Nagata
|
| gptkbp:discoveredIn |
1986
|
| gptkbp:encodedBy |
CSF3 gene
|
| gptkbp:function |
promotes neutrophil proliferation and differentiation
stimulates bone marrow to produce granulocytes stimulates bone marrow to produce stem cells |
| gptkbp:GO_term |
GO:0005127
|
| gptkbp:hasApprovedDrug |
gptkb:filgrastim
gptkb:pegfilgrastim lenograstim lipegfilgrastim |
| https://www.w3.org/2000/01/rdf-schema#label |
granulocyte colony-stimulating factor
|
| gptkbp:MeSH_ID |
D016153
|
| gptkbp:molecularWeight |
18.8 kDa
|
| gptkbp:orthologIn |
granulocyte-macrophage colony-stimulating factor
macrophage colony-stimulating factor |
| gptkbp:producedBy |
macrophages
endothelial cells fibroblasts |
| gptkbp:PubChem_CID |
CHEBI:50141
|
| gptkbp:recipient |
G-CSF receptor
|
| gptkbp:routeOfAdministration |
subcutaneous injection
intravenous injection |
| gptkbp:sideEffect |
fever
splenomegaly bone pain allergic reactions |
| gptkbp:structureType |
single-chain glycoprotein
|
| gptkbp:UNII |
PDB4HS6X4D
|
| gptkbp:usedFor |
treatment of neutropenia
mobilization of hematopoietic stem cells support during chemotherapy |
| gptkbp:bfsParent |
gptkb:GSD_Ib
gptkb:glucose-6-phosphate_translocase_deficiency gptkb:plerixafor gptkb:Pegfilgrastim gptkb:filgrastim gptkb:pegfilgrastim |
| gptkbp:bfsLayer |
8
|