fatty acid amide hydrolase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:abbreviation	gptkb:FAAH
gptkbp:activeSiteResidue	serine
gptkbp:alternativeName	gptkb:amidase_signature_family_protein gptkb:anandamide_amidohydrolase gptkb:oleamide_hydrolase
gptkbp:associatedWith	anxiety pain modulation inflammation
gptkbp:catalyzes	hydrolysis of anandamide hydrolysis of fatty acid amides hydrolysis of oleamide
gptkbp:EC_number	3.5.1.99
gptkbp:encodedBy	gptkb:FAAH_gene
gptkbp:expressedIn	gptkb:kidney gptkb:small_intestine gptkb:testis brain liver
gptkbp:foundIn	humans mammals
gptkbp:gene	gptkb:FAAH
https://www.w3.org/2000/01/rdf-schema#label	fatty acid amide hydrolase
gptkbp:inhibitedBy	gptkb:AM3506 gptkb:PF-04457845 gptkb:URB597
gptkbp:inhibitor_clinical_trial	gptkb:PF-04457845
gptkbp:involves	gptkb:endocannabinoid_system
gptkbp:locatedIn	gptkb:endoplasmic_reticulum gptkb:cell_membrane
gptkbp:locatedOnChromosome	1p33
gptkbp:molecularWeight	~63 kDa
gptkbp:mutationAssociatedWith	pain insensitivity increased anandamide levels
gptkbp:OMIM	602935
gptkbp:orthologInMouse	gptkb:Faah
gptkbp:PDB	gptkb:1MT5 gptkb:2VYA
gptkbp:product	fat ethanolamine
gptkbp:regulates	levels of anandamide levels of fatty acid amides
gptkbp:structure	serine hydrolase
gptkbp:substrate	gptkb:anandamide gptkb:linoleoylethanolamide gptkb:oleamide gptkb:palmitoylethanolamide gptkb:stearoylethanolamide
gptkbp:UniProtID	gptkb:O00519
gptkbp:bfsParent	gptkb:endocannabinoid_system
gptkbp:bfsLayer	6