|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:FAAM
AMID
OLEAMIDE HYDROLASE
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
addiction
obesity
anxiety
pain insensitivity
|
|
gptkbp:clinicalTrialPhase
|
BIA 10-2474 trial (2016)
|
|
gptkbp:discoveredBy
|
Cravatt et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
fatty acid amide hydrolase enzyme
|
|
gptkbp:Entrez_Gene_ID
|
2166
ENSG00000184012
|
|
gptkbp:enzymeCommissionNumber
|
3.5.1.99
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
gptkb:testis
brain
liver
|
|
gptkbp:fullName
|
gptkb:fatty_acid_amide_hydrolase
|
|
gptkbp:function
|
regulates appetite
regulates mood
degrades endocannabinoids
hydrolyzes fatty acid amides
regulates pain sensation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
3573
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FAAH gene
|
|
gptkbp:inhibitedBy
|
gptkb:PF-04457845
gptkb:URB597
BIA 10-2474
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1p33
|
|
gptkbp:mutationAssociatedWith
|
C385A
P129T
|
|
gptkbp:OMIM
|
602935
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Faah
|
|
gptkbp:pathway
|
gptkb:endocannabinoid_signaling_pathway
fatty acid metabolism
|
|
gptkbp:proteinFamily
|
amidase signature family
|
|
gptkbp:substrate
|
gptkb:anandamide
gptkb:oleamide
gptkb:palmitoylethanolamide
gptkb:stearoylethanolamide
|
|
gptkbp:UniProtID
|
gptkb:O00519
|
|
gptkbp:bfsParent
|
gptkb:fatty_acid_amide_hydrolase
|
|
gptkbp:bfsLayer
|
7
|