|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:amidase_signature_family_protein
gptkb:oleamide_hydrolase
|
|
gptkbp:associatedWith
|
addiction
pain
anxiety
inflammation
|
|
gptkbp:clinicalTrialPhase
|
BIA 10-2474 (terminated due to adverse effects)
|
|
gptkbp:cofactor
|
none
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:EC_number
|
3.5.1.99
|
|
gptkbp:enzymeClassification
|
gptkb:hydrolase
|
|
gptkbp:fullName
|
Fatty acid amide hydrolase
|
|
gptkbp:function
|
degrades endocannabinoids
hydrolyzes fatty acid amides
|
|
gptkbp:gene
|
gptkb:FAAH
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FAAH
|
|
gptkbp:inhibitedBy
|
gptkb:PF-04457845
gptkb:URB597
BIA 10-2474
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1p33
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:kidney
gptkb:testis
brain
liver
|
|
gptkbp:molecularWeight
|
63 kDa
|
|
gptkbp:mutationAssociatedWith
|
C385A (associated with altered pain sensitivity)
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse FAAH
rat FAAH
|
|
gptkbp:pathway
|
endocannabinoid signaling
|
|
gptkbp:PDB
|
gptkb:1MT5
gptkb:2VYA
3QK5
|
|
gptkbp:regulates
|
regulated by phosphorylation
inhibited by endocannabinoids
|
|
gptkbp:relatedTo
|
pain modulation
neurotransmission
inflammatory response
|
|
gptkbp:structure
|
dimer
|
|
gptkbp:substrate
|
gptkb:anandamide
gptkb:oleamide
gptkb:palmitoylethanolamide
N-acylethanolamines
fatty acid ethanolamides
|
|
gptkbp:UniProtID
|
gptkb:O00519
|
|
gptkbp:bfsParent
|
gptkb:fatty_acid_amide_hydrolase
|
|
gptkbp:bfsLayer
|
7
|