familial amyotrophic lateral sclerosis

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease neurodegenerative disease genetic disorder
gptkbp:affects	gptkb:nervous_system motor neurons
gptkbp:alsoKnownAs	gptkb:familial_ALS fALS
gptkbp:associatedWith	gptkb:VCP gptkb:ANG gptkb:C9orf72 gptkb:FUS gptkb:SOD1 gptkb:TARDBP gptkb:UBQLN2 gptkb:ALS2 gptkb:OPTN gptkb:SETX
gptkbp:complication	gptkb:pneumonia malnutrition respiratory failure paralysis
gptkbp:field	genetics neurology
gptkbp:firstDescribed	19th century
https://www.w3.org/2000/01/rdf-schema#label	familial amyotrophic lateral sclerosis
gptkbp:ICD-10_code	G12.2
gptkbp:inheritance	autosomal dominant autosomal recessive
gptkbp:MeSH_ID	D000690
gptkbp:namedAfter	amyotrophic lateral sclerosis
gptkbp:OMIM	105400
gptkbp:onset	adulthood
gptkbp:prevalence	5-10% of ALS cases
gptkbp:prognosis	progressive fatal
gptkbp:relatedTo	sporadic amyotrophic lateral sclerosis
gptkbp:riskFactor	family history of ALS
gptkbp:symptom	respiratory failure difficulty speaking difficulty swallowing muscle atrophy muscle weakness
gptkbp:treatment	gptkb:edaravone gptkb:riluzole
gptkbp:bfsParent	gptkb:ALS1
gptkbp:bfsLayer	6