dementia with Lewy bodies

URI: https://gptkb.org/entity/dementia_with_Lewy_bodies
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:dementia
neurodegenerative disease
gptkbp:affects older adults
gptkbp:alsoKnownAs gptkb:DLB
gptkbp:associatedWith GBA gene mutation (rarely)
gptkbp:causedBy Lewy bodies
gptkbp:complication falls
delirium
sensitivity to antipsychotics
gptkbp:differentialDiagnosis gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease_dementia
frontotemporal dementia
gptkbp:firstDescribed gptkb:Kenji_Kosaka
1976
gptkbp:hasAutonomicSymptoms gptkb:orthostatic_hypotension
urinary incontinence
gptkbp:hasAverageSurvival 5-8 years after diagnosis
gptkbp:hasBiomarker gptkb:alpha-synuclein
gptkbp:hasCognitiveProfile attention and executive dysfunction
gptkbp:hasDiagnosticCriteria gptkb:McKeith_criteria
gptkbp:hasEpidemiology accounts for 10-15% of dementia cases
gptkbp:hasImagingFinding reduced dopamine transporter uptake in basal ganglia
gptkbp:hasMotorSymptoms parkinsonism
gptkbp:hasOrphanetID ORPHA:705
gptkbp:hasSleepDisorder gptkb:REM_sleep_behavior_disorder
https://www.w3.org/2000/01/rdf-schema#label dementia with Lewy bodies
gptkbp:ICD-10_code G31.8
gptkbp:inheritance sporadic
gptkbp:MeSH_ID gptkb:D000544
gptkbp:mortalityRate increased
gptkbp:offersCourse fluctuating
gptkbp:OMIM 127750
gptkbp:onset insidious
gptkbp:pathology alpha-synuclein aggregation
gptkbp:prevalence second most common degenerative dementia after Alzheimer's disease
gptkbp:prognosis progressive
gptkbp:relatedTo gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkbp:riskFactor age
male sex
gptkbp:symptom gptkb:REM_sleep_behavior_disorder
autonomic dysfunction
parkinsonism
visual hallucinations
cognitive fluctuations
gptkbp:treatment cholinesterase inhibitors
antipsychotics (with caution)
levodopa (for parkinsonism)
gptkbp:bfsParent gptkb:Mervyn_Peake
gptkb:Lewy_body_disease
gptkbp:bfsLayer 6