|
gptkbp:instanceOf
|
gptkb:antibiotic
gptkb:drug
|
|
gptkbp:ATCCode
|
J04BA02
|
|
gptkbp:brand
|
Aczone
Avlosulfon
|
|
gptkbp:CASNumber
|
80-08-0
|
|
gptkbp:category
|
gptkb:WHO_essential_medicines
antimycobacterial drug
|
|
gptkbp:cause
|
aplastic anemia
hypersensitivity syndrome
agranulocytosis
|
|
gptkbp:chemicalFormula
|
C12H12N2O2S
|
|
gptkbp:combines
|
gptkb:rifampicin
gptkb:clofazimine
pyrimethamine
trimethoprim
|
|
gptkbp:contraindication
|
gptkb:G6PD_deficiency
severe anemia
|
|
gptkbp:discoveredBy
|
Ernst Fourneau
|
|
gptkbp:discoveredIn
|
1937
|
|
gptkbp:drugClass
|
sulfones
|
|
gptkbp:eliminationHalfLife
|
20-30 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:has_generic_name
|
gptkb:dapsone
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
dapsone
|
|
gptkbp:is_on_WHO_Model_List_of_Essential_Medicines
|
true
|
|
gptkbp:IUPACName
|
4,4'-diaminodiphenyl sulfone
|
|
gptkbp:KEGGID
|
D00279
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits dihydropteroate synthase
|
|
gptkbp:meltingPoint
|
175-176°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
248.30 g/mol
|
|
gptkbp:pregnancyCategory
|
A
C
|
|
gptkbp:PubChem_CID
|
2851
2955
CHEMBL1389
DB00250
|
|
gptkbp:routeOfAdministration
|
oral
topical
|
|
gptkbp:sideEffect
|
gptkb:methemoglobinemia
nausea
rash
hemolysis
|
|
gptkbp:UNII
|
8W5C518302
|
|
gptkbp:usedFor
|
gptkb:Pneumocystis_jirovecii_pneumonia
gptkb:toxoplasmosis
leprosy
dermatitis herpetiformis
|
|
gptkbp:bfsParent
|
gptkb:Pneumocystis_jirovecii
gptkb:Methemoglobinemia
|
|
gptkbp:bfsLayer
|
6
|