cystathionine gamma-lyase

URI: https://gptkb.org/entity/cystathionine_gamma-lyase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:alternativeName	gptkb:cystathionase gptkb:cystathionine_lyase gptkb:CGL
gptkbp:associatedWith	oxidative stress response inflammatory response cardiovascular function cystathioninuria
gptkbp:catalyzes	conversion of cystathionine to cysteine, ammonia, and alpha-ketobutyrate
gptkbp:cofactor	gptkb:pyridoxal_phosphate
gptkbp:EC_number	4.4.1.1
gptkbp:enzyme_subclass	carbon-sulfur lyase
gptkbp:enzymeClassification	lyase
gptkbp:expressedIn	gptkb:kidney brain liver vascular tissue
gptkbp:foundIn	gptkb:yeast gptkb:Bacteria humans
gptkbp:gene	gptkb:CTH
gptkbp:gene_location_(mouse)	gptkb:chromosome_4
gptkbp:gene_location_(rat)	gptkb:chromosome_5
https://www.w3.org/2000/01/rdf-schema#label	cystathionine gamma-lyase
gptkbp:inhibitedBy	gptkb:DL-propargylglycine gptkb:beta-cyanoalanine gptkb:propargylglycine
gptkbp:involves	transsulfuration pathway
gptkbp:locatedOnChromosome	gptkb:1p31.1
gptkbp:molecularWeight	~44 kDa (per subunit)
gptkbp:OMIM	607657
gptkbp:pathway	cysteine biosynthesis methionine metabolism hydrogen sulfide biosynthesis
gptkbp:PDB	gptkb:1CL2
gptkbp:produces	gptkb:hydrogen_sulfide
gptkbp:product	gptkb:hydrogen_sulfide ammonia cysteine alpha-ketobutyrate
gptkbp:requires	cysteine homeostasis homocysteine metabolism hydrogen sulfide signaling
gptkbp:structure	homotetramer
gptkbp:substrate	cystathionine
gptkbp:UniProtID	gptkb:P32929
gptkbp:bfsParent	gptkb:pyridoxal_phosphate
gptkbp:bfsLayer	7