Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Biology
|
| gptkbp:clinical_trial |
elevated levels indicate muscle damage
|
| gptkbp:condition |
gptkb:Cardiology
hypothyroidism strenuous exercise rhabdomyolysis muscle dystrophies |
| gptkbp:discovery |
discovered in the 1950s
|
| gptkbp:elevation_causes |
gptkb:surgery
heart attack stroke intense exercise certain medications severe infections muscle injury |
| gptkbp:frequency |
often tested in emergency settings
used in routine health check-ups |
| gptkbp:full_name |
creatine phosphokinase
|
| gptkbp:function |
catalyzes the phosphorylation of creatine to phosphocreatine
|
| gptkbp:genetic_studies |
genetic mutations can affect levels
|
| https://www.w3.org/2000/01/rdf-schema#label |
CPK
|
| gptkbp:importance |
used as a biomarker for myocardial infarction
|
| gptkbp:inhibition |
can be inhibited by certain drugs
|
| gptkbp:is_monitored_by |
monitored in athletes
monitored in patients with heart disease monitored in patients with muscle disorders |
| gptkbp:is_tested_for |
blood test
|
| gptkbp:isoforms |
three main isoforms: CPK-MM, CPK-MB, CPK-BB
|
| gptkbp:laboratory_methods |
measured using enzyme-linked immunosorbent assay (ELISA)
measured using mass spectrometry measured using spectrophotometry |
| gptkbp:location |
found in the heart, brain, and skeletal muscle
|
| gptkbp:measures |
measured in units per liter (U/ L)
|
| gptkbp:normal_range |
typically 20 to 200 U/ L
|
| gptkbp:provides_guidance_on |
guidelines exist for follow-up testing
guidelines exist for interpreting results guidelines exist for treatment decisions |
| gptkbp:related_enzymes |
gptkb:aldolase
gptkb:aspartate_aminotransferase gptkb:lactate_dehydrogenase alanine aminotransferase |
| gptkbp:research |
exploration of therapeutic targets related to CPK
ongoing research into its role in disease studies on genetic variations affecting levels investigations into new biomarkers for heart disease |
| gptkbp:treatment_implications |
high levels may require further investigation
low levels may indicate muscle wasting |
| gptkbp:bfsParent |
gptkb:CPK_Holdings,_Inc.
|
| gptkbp:bfsLayer |
6
|