Statements (40)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeTo |
innexins (in invertebrates)
pannexins (in vertebrates) |
| gptkbp:assembleToForm |
gap junctions
hemichannels (connexons) |
| gptkbp:degradedBy |
gptkb:lysosome
gptkb:proteasome |
| gptkbp:discoveredBy |
Jean-Paul Revel
M. J. Karnovsky |
| gptkbp:encodedBy |
GJA gene family
|
| gptkbp:example |
Connexin 26 (GJB2)
Connexin 32 (GJB1) Connexin 36 (GJD2) Connexin 43 (GJA1) |
| gptkbp:firstDescribed |
1967
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
form gap junction channels
|
| https://www.w3.org/2000/01/rdf-schema#label |
connexins
|
| gptkbp:involvedIn |
cell-cell communication
electrical coupling metabolic coupling |
| gptkbp:mutationAssociatedWith |
deafness
neurological disorders skin disorders cardiac arrhythmias |
| gptkbp:numberOfGenes |
21
|
| gptkbp:presentIn |
gptkb:skin
brain heart liver lens of the eye |
| gptkbp:regulates |
phosphorylation
sumoylation ubiquitination |
| gptkbp:structure |
four transmembrane domains
cytoplasmic N- and C-termini one intracellular loop two extracellular loops |
| gptkbp:bfsParent |
gptkb:GJB1
|
| gptkbp:bfsLayer |
7
|