Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
complement system component |
| gptkbp:activatedBy |
gptkb:lectin_pathway
alternative pathway classical pathway |
| gptkbp:alternativeName |
C3
complement component 3 |
| gptkbp:associatedWith |
gptkb:C3_glomerulopathy
gptkb:systemic_lupus_erythematosus age-related macular degeneration |
| gptkbp:cleavage |
gptkb:C3b
C3a |
| gptkbp:deficiencyCauses |
increased susceptibility to bacterial infections
|
| gptkbp:discoveredIn |
1960s
|
| gptkbp:encodedBy |
C3 gene
|
| gptkbp:foundIn |
gptkb:human
other mammals |
| gptkbp:function |
immune response
opsonization activation of complement system |
| https://www.w3.org/2000/01/rdf-schema#label |
complement protein C3
|
| gptkbp:locatedOnChromosome |
gptkb:19p13.3
|
| gptkbp:location |
blood plasma
|
| gptkbp:molecularWeight |
~187 kDa
|
| gptkbp:OMIM |
120700
|
| gptkbp:partOf |
innate immune system
|
| gptkbp:PDB |
2A73
|
| gptkbp:structure |
contains alpha and beta chains
|
| gptkbp:synthesisType |
liver
|
| gptkbp:UniProtID |
P01024
|
| gptkbp:bfsParent |
gptkb:Syfovre
|
| gptkbp:bfsLayer |
8
|