bromodomain and extraterminal domain proteins
GPTKB entity
Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
BET proteins
|
| gptkbp:binds |
acetylated lysine residues on histones
|
| gptkbp:discoveredBy |
1990s
|
| gptkbp:domain |
gptkb:bromodomain
extraterminal domain |
| gptkbp:function |
regulation of gene expression
|
| https://www.w3.org/2000/01/rdf-schema#label |
bromodomain and extraterminal domain proteins
|
| gptkbp:involves |
gptkb:cancer
gptkb:cardiovascular_disease neurological disorders inflammation transcriptional regulation |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:member |
BRD4
BRD2 BRD3 BRDT |
| gptkbp:orthologIn |
mammals
vertebrates |
| gptkbp:role |
cell cycle regulation
chromatin remodeling |
| gptkbp:studiedBy |
epigenetics
|
| gptkbp:target |
BET inhibitors
I-BET762 JQ1 |
| gptkbp:bfsParent |
gptkb:KT-333
|
| gptkbp:bfsLayer |
8
|