|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
water channel protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:criteria
|
small solutes
water molecules
|
|
gptkbp:discoveredBy
|
gptkb:Peter_Agre
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cataracts
gptkb:nephrogenic_diabetes_insipidus
brain edema
|
|
gptkbp:encodedBy
|
AQP genes
|
|
gptkbp:evolutionaryConservation
|
high
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:foundIn
|
gptkb:cell_membrane
|
|
gptkbp:function
|
water channel
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
aquaporin
|
|
gptkbp:inhibitedBy
|
mercury compounds
|
|
gptkbp:locale
|
gptkb:plasma_membrane
intracellular membranes
|
|
gptkbp:molecularWeight
|
~28 kDa (AQP1)
|
|
gptkbp:NobelPrizeYear
|
2003 Chemistry
|
|
gptkbp:presentIn
|
gptkb:Bacteria
animals
plants
|
|
gptkbp:proteinFamily
|
MIP family
|
|
gptkbp:regulates
|
water transport
|
|
gptkbp:requires
|
urine concentration
cellular osmoregulation
cerebrospinal fluid homeostasis
plant drought resistance
|
|
gptkbp:role
|
kidney function
brain water homeostasis
plant water regulation
|
|
gptkbp:structure
|
six transmembrane helices
|
|
gptkbp:subspecies
|
AQP4
AQP3
AQP1
AQP10
AQP11
AQP12
AQP2
AQP5
AQP6
AQP7
AQP8
AQP9
|
|
gptkbp:transportedMolecule
|
gptkb:water
glycerol (some subtypes)
urea (some subtypes)
|
|
gptkbp:bfsParent
|
gptkb:transport_proteins
|
|
gptkbp:bfsLayer
|
7
|