anaplastic thyroid carcinoma

URI: https://gptkb.org/entity/anaplastic_thyroid_carcinoma
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:cancer
gptkbp:affectsOrgan thyroid gland
gptkbp:alternativeName undifferentiated thyroid carcinoma
gptkbp:differentialDiagnosis gptkb:medullary_thyroid_carcinoma
leukemia
metastatic carcinoma
gptkbp:firstDescribed 1907
gptkbp:hasCommonGender female
male
gptkbp:hasCommonSpreadTo brain
lungs
bones
gptkbp:hasCommonSymptoms hoarseness
dyspnea
dysphagia
rapidly enlarging neck mass
gptkbp:hasGeneticAlteration gptkb:TP53_mutation
BRAF mutation
TERT promoter mutation
gptkbp:hasICD-O-3Code 8021/3
gptkbp:hasMedianSurvival less than 6 months
gptkbp:hasMetastasisRate high
gptkbp:hasPercentageOfThyroidCancers less than 2%
gptkbp:hasStageAtDiagnosis usually stage IV
gptkbp:hasTypicalAgeOfOnset over 60 years
gptkbp:histology spindle cells
pleomorphic giant cells
squamoid cells
https://www.w3.org/2000/01/rdf-schema#label anaplastic thyroid carcinoma
gptkbp:ICD-10_code gptkb:C73
gptkbp:location anterior neck
gptkbp:mortalityRate very high
gptkbp:originatedIn follicular cells
gptkbp:prevalence rare
gptkbp:prognosis poor
tumor size
patient age
extent of disease
gptkbp:riskFactor older age
history of goiter
previous thyroid disease
gptkbp:stageName gptkb:AJCC_TNM
gptkbp:treatment surgery
radiation therapy
chemotherapy
targeted therapy
gptkbp:bfsParent gptkb:Undifferentiated_thyroid_carcinoma
gptkbp:bfsLayer 6