anaplastic thyroid carcinoma

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cancer
gptkbp:affectsOrgan	thyroid gland
gptkbp:alternativeName	undifferentiated thyroid carcinoma
gptkbp:differentialDiagnosis	gptkb:leukemia gptkb:medullary_thyroid_carcinoma metastatic carcinoma
gptkbp:firstDescribed	1907
gptkbp:hasCommonGender	gptkb:female gptkb:male
gptkbp:hasCommonSpreadTo	brain lungs bones
gptkbp:hasCommonSymptoms	hoarseness dyspnea dysphagia rapidly enlarging neck mass
gptkbp:hasGeneticAlteration	gptkb:TP53_mutation BRAF mutation TERT promoter mutation
gptkbp:hasICD-O-3Code	8021/3
gptkbp:hasMedianSurvival	less than 6 months
gptkbp:hasMetastasisRate	high
gptkbp:hasPercentageOfThyroidCancers	less than 2%
gptkbp:hasStageAtDiagnosis	usually stage IV
gptkbp:hasTypicalAgeOfOnset	over 60 years
gptkbp:histology	spindle cells pleomorphic giant cells squamoid cells
gptkbp:ICD-10_code	gptkb:C73
gptkbp:location	anterior neck
gptkbp:mortalityRate	very high
gptkbp:originatedIn	follicular cells
gptkbp:prevalence	rare
gptkbp:prognosis	poor tumor size patient age extent of disease
gptkbp:riskFactor	older age history of goiter previous thyroid disease
gptkbp:stageName	gptkb:AJCC_TNM
gptkbp:treatment	gptkb:radiation_therapy gptkb:targeted_therapy surgery chemotherapy
gptkbp:bfsParent	gptkb:thyroid_gland_neoplasms gptkb:Neoplasms,_Thyroid gptkb:Thyroid_Gland_Neoplasms gptkb:RET_fusion-positive_thyroid_cancer
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	anaplastic thyroid carcinoma