alpha-ketoglutarate dehydrogenase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:activatedBy	calcium ions
gptkbp:alternativeName	gptkb:2-oxoglutarate_dehydrogenase gptkb:OGDH gptkb:alpha-ketoglutarate_oxidoreductase
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:Wernicke-Korsakoff_syndrome neurodegenerative diseases
gptkbp:catalyzes	conversion of alpha-ketoglutarate to succinyl-CoA
gptkbp:cofactor	gptkb:Coenzyme_A gptkb:FAD NAD+ thiamine pyrophosphate lipoic acid
gptkbp:component	gptkb:alpha-ketoglutarate_dehydrogenase_complex
gptkbp:EC_number	1.2.4.2
gptkbp:foundIn	mitochondria
gptkbp:gene	gptkb:OGDH
gptkbp:inhibitedBy	gptkb:NADH gptkb:succinyl-CoA arsenite
gptkbp:pathway	citric acid cycle
gptkbp:product	gptkb:NADH gptkb:succinyl-CoA CO2
gptkbp:substrate	gptkb:alpha-ketoglutarate
gptkbp:systematicName	gptkb:2-oxoglutarate:acceptor_oxidoreductase_(decarboxylating_and_thiamin_diphosphate-dependent)
gptkbp:bfsParent	gptkb:Krebs_cycle
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	alpha-ketoglutarate dehydrogenase