alpha-ketoglutarate dehydrogenase

URI: https://gptkb.org/entity/alpha-ketoglutarate_dehydrogenase
GPTKB entity
Statements (31)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy calcium ions
gptkbp:alternativeName gptkb:2-oxoglutarate_dehydrogenase
gptkb:OGDH
gptkb:alpha-ketoglutarate_oxidoreductase
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:Wernicke-Korsakoff_syndrome
neurodegenerative diseases
gptkbp:catalyzes conversion of alpha-ketoglutarate to succinyl-CoA
gptkbp:cofactor gptkb:Coenzyme_A
gptkb:FAD
NAD+
thiamine pyrophosphate
lipoic acid
gptkbp:component gptkb:alpha-ketoglutarate_dehydrogenase_complex
gptkbp:EC_number 1.2.4.2
gptkbp:foundIn mitochondria
gptkbp:gene gptkb:OGDH
https://www.w3.org/2000/01/rdf-schema#label alpha-ketoglutarate dehydrogenase
gptkbp:inhibitedBy gptkb:NADH
gptkb:succinyl-CoA
arsenite
gptkbp:pathway citric acid cycle
gptkbp:product gptkb:NADH
gptkb:succinyl-CoA
CO2
gptkbp:substrate gptkb:alpha-ketoglutarate
gptkbp:systematicName gptkb:2-oxoglutarate:acceptor_oxidoreductase_(decarboxylating_and_thiamin_diphosphate-dependent)
gptkbp:bfsParent gptkb:Krebs_cycle
gptkb:Vitamin_B1
gptkbp:bfsLayer 5