2-oxoglutarate dehydrogenase

URI: https://gptkb.org/entity/2-oxoglutarate_dehydrogenase
GPTKB entity
Statements (35)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:alpha-ketoglutarate_dehydrogenase
gptkb:OGDH
alpha-KGDH
gptkbp:associatedWith neurodegenerative diseases
thiamine deficiency
gptkbp:biologicalProcess oxidoreductase activity
gptkbp:catalyzes oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA
gptkbp:cofactor gptkb:Coenzyme_A
gptkb:FAD
NAD+
thiamine pyrophosphate
lipoic acid
gptkbp:EC_number 1.2.4.2
gptkbp:foundIn mitochondria
gptkbp:gene DLD (E3 subunit)
DLST (E2 subunit)
OGDH (E1 subunit)
https://www.w3.org/2000/01/rdf-schema#label 2-oxoglutarate dehydrogenase
gptkbp:inhibitedBy gptkb:NADH
gptkb:succinyl-CoA
arsenite
gptkbp:participatedIn energy metabolism
gptkbp:pathway citric acid cycle
gptkbp:product gptkb:NADH
gptkb:succinyl-CoA
CO2
gptkbp:structure multienzyme complex
gptkbp:substrate gptkb:2-oxoglutarate
gptkbp:subunit E1 (OGDH)
E2 (DLST)
E3 (DLD)
gptkbp:systematicName 2-oxoglutarate:lipoyltransferase oxidoreductase (decarboxylating and succinyl-transferring)
gptkbp:bfsParent gptkb:alpha-ketoglutarate_dehydrogenase
gptkbp:bfsLayer 6