adipose triglyceride lipase

URI: https://gptkb.org/entity/adipose_triglyceride_lipase
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy CGI-58
gptkbp:activity triacylglycerol hydrolase
gptkbp:alsoKnownAs gptkb:ATGL
patatin-like phospholipase domain-containing protein 2
gptkbp:associatedWith gptkb:neutral_lipid_storage_disease
muscular dystrophy
gptkbp:cofactor none required
gptkbp:discoveredBy 2004
gptkbp:EC_number 3.1.1.3
gptkbp:expressedIn gptkb:skeletal_muscle
gptkb:testis
heart
liver
macrophages
adipocytes
gptkbp:family patatin-like phospholipase family
gptkbp:function hydrolyzes triglycerides into diacylglycerol and free fatty acids
gptkbp:gene gptkb:PNPLA2
https://www.w3.org/2000/01/rdf-schema#label adipose triglyceride lipase
gptkbp:inhibitedBy gptkb:G0S2
gptkbp:locatedOnChromosome gptkb:11p15.5
11
gptkbp:location gptkb:skeletal_muscle
adipose tissue
cytosol
lipid droplet surface
gptkbp:molecularWeight 54 kDa
gptkbp:mutationAssociatedWith causes neutral lipid storage disease with myopathy
gptkbp:OMIM 609059
gptkbp:orthologIn gptkb:mouse
gptkb:zebrafish
gptkb:Drosophila_melanogaster
right
gptkbp:pathway lipolysis
gptkbp:PDB 6VHV
gptkbp:product diacylglycerol
free fatty acids
gptkbp:regulates inhibited by G0/G1 switch gene 2 (G0S2)
activated by comparative gene identification-58 (CGI-58)
gptkbp:role energy homeostasis
mobilization of stored fat
gptkbp:significance target for metabolic disease therapy
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure contains patatin domain
gptkbp:substrate triglyceride
gptkbp:UniProtID gptkb:Q96AD5
gptkbp:bfsParent gptkb:PNPLA2_gene
gptkb:PNPLA2
gptkbp:bfsLayer 8