acid-sensing ion channels (ASICs)
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
extracellular acidification
|
| gptkbp:alternativeName |
ACCN channels
acid-gated ion channels proton-gated cation channels |
| gptkbp:discoveredIn |
1997
|
| gptkbp:encodedBy |
ACCN genes
|
| gptkbp:enemyOf |
gptkb:protons
gptkb:amiloride APETx2 psalmotoxin 1 |
| gptkbp:expressedIn |
gptkb:neurons
glial cells |
| gptkbp:foundIn |
animals
central nervous system peripheral nervous system |
| gptkbp:function |
proton-gated ion channel
|
| gptkbp:involvedIn |
gptkb:synaptic_plasticity
neurodegeneration mechanosensation pain sensation |
| gptkbp:memberOf |
ENaC/DEG family
|
| gptkbp:modulatedBy |
gptkb:arachidonic_acid
zinc calcium lactate serotonin polyamines neuropeptides redox state |
| gptkbp:permeableTo |
sodium ions
|
| gptkbp:proteinFamily |
ACCN1
ACCN2 ACCN3 ACCN4 ACCN5 |
| gptkbp:relatedTo |
gptkb:depression
epilepsy multiple sclerosis anxiety ischemic brain injury |
| gptkbp:structure |
trimeric
|
| gptkbp:subunit |
ASIC1
ASIC2 ASIC3 ASIC4 ASIC5 |
| gptkbp:bfsParent |
gptkb:DEG/ENaC_family
|
| gptkbp:bfsLayer |
8
|
| http://www.w3.org/2000/01/rdf-schema#label |
acid-sensing ion channels (ASICs)
|