|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:ACACA
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:cofactor
|
gptkb:ATP
gptkb:biotin
Mg2+
|
|
gptkbp:encodes
|
acetyl-CoA carboxylase 1
|
|
gptkbp:Entrez_Gene_ID
|
31
|
|
gptkbp:enzymeCommissionNumber
|
6.4.1.2
|
|
gptkbp:expressedIn
|
liver
adipose tissue
mammary gland
|
|
gptkbp:function
|
catalyzes carboxylation of acetyl-CoA to malonyl-CoA
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ACC1
|
|
gptkbp:inhibitedBy
|
TOFA
soraphen A
CP-640186
|
|
gptkbp:involves
|
fatty acid biosynthesis
|
|
gptkbp:length
|
2346
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q12
|
|
gptkbp:molecularWeight
|
265 kDa
|
|
gptkbp:mutationAssociatedWith
|
altered lipid metabolism
|
|
gptkbp:OMIM
|
200350
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Acaca
|
|
gptkbp:pathway
|
lipogenesis
fatty acid metabolism
|
|
gptkbp:product
|
gptkb:acetyl-CoA_carboxylase_alpha
|
|
gptkbp:regulates
|
inhibited by phosphorylation
allosterically regulated by citrate
|
|
gptkbp:subcellularLocation
|
cytosol
|
|
gptkbp:UniProtID
|
gptkb:Q13085
|
|
gptkbp:bfsParent
|
gptkb:ACACA
|
|
gptkbp:bfsLayer
|
7
|