Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
WD-repeat proteins
|
| gptkbp:bindingPartner |
nucleic acids
proteins small molecules |
| gptkbp:characterizedBy |
WD40 repeat domain
|
| gptkbp:conservedIn |
GH dipeptide
WD dipeptide |
| gptkbp:database |
gptkb:UniProt
gptkb:InterPro gptkb:SMART gptkb:PROSITE gptkb:Pfam |
| gptkbp:domain |
gptkb:protein
|
| gptkbp:evolutionaryConservation |
high
|
| gptkbp:example |
gptkb:EED
gptkb:WDR5 gptkb:DDB1 Cdc4 Gβ subunit of heterotrimeric G proteins Tup1 transcriptional corepressor |
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:function |
signal transduction
protein-protein interaction scaffolding transcription regulation cell cycle control chromatin assembly |
| gptkbp:GO_term |
GO:0005737 (cytoplasm)
GO:0005634 (nucleus) GO:0005515 (protein binding) |
| https://www.w3.org/2000/01/rdf-schema#label |
WD40 proteins
|
| gptkbp:InterPro |
IPR001680
|
| gptkbp:numberOfArabidopsisGenes |
~200
|
| gptkbp:numberOfGenes |
~250
|
| gptkbp:numberOfRepeats |
4-16
|
| gptkbp:proteinFamily |
PF00400
|
| gptkbp:repeatLength |
~40 amino acids
|
| gptkbp:repeatMotif |
tryptophan-aspartic acid (WD) dipeptide
|
| gptkbp:role |
gptkb:cancer
neurodegenerative diseases developmental disorders |
| gptkbp:structure |
beta-propeller
7-bladed beta-propeller circular symmetry |
| gptkbp:bfsParent |
gptkb:WD_repeat
|
| gptkbp:bfsLayer |
7
|