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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alternativeName
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gptkb:Factor_VIII-related_antigen
gptkb:VWF
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gptkbp:associatedWith
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gptkb:Von_Willebrand_disease
|
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gptkbp:binds
|
collagen
factor VIII
platelet glycoprotein Ib (GPIb)
|
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gptkbp:clinicalTrialPhase
|
VWF antigen assay
ristocetin cofactor activity
|
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gptkbp:deficiencyCauses
|
bleeding disorder
|
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gptkbp:degradedBy
|
ADAMTS13
|
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gptkbp:discoveredBy
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gptkb:Erik_Adolf_von_Willebrand
|
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gptkbp:encodedBy
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gptkb:VWF_gene
|
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gptkbp:foundIn
|
blood plasma
|
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gptkbp:function
|
binds to factor VIII
mediates platelet adhesion
|
|
gptkbp:glycosylation
|
heavily glycosylated
|
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gptkbp:halfLife
|
~12 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Von Willebrand factor
|
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gptkbp:involvedIn
|
secondary hemostasis
primary hemostasis
|
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gptkbp:locatedOnChromosome
|
12p13.3
|
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gptkbp:location
|
Weibel-Palade bodies of endothelial cells
alpha-granules of platelets
|
|
gptkbp:molecularWeight
|
~270 kDa (monomer)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Von_Willebrand_disease
|
|
gptkbp:presentIn
|
humans
other mammals
|
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gptkbp:role
|
hemostasis
|
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gptkbp:structure
|
multimeric protein
|
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gptkbp:synthesisType
|
gptkb:megakaryocytes
endothelial cells
|
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gptkbp:bfsParent
|
gptkb:Platelet
|
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gptkbp:bfsLayer
|
5
|