Valacyclovir

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf antiviral drug
prodrug
gptkbp:approvalYear 1995
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode J05AB11
gptkbp:bioavailability 54%
gptkbp:brand gptkb:Valtrex
gptkbp:CASNumber 124832-27-5
gptkbp:chemicalFormula C13H20N6O4
gptkbp:contraindication hypersensitivity to acyclovir
hypersensitivity to valacyclovir
gptkbp:developedBy GlaxoSmithKline
gptkbp:discoveredBy GlaxoSmithKline
gptkbp:eliminationHalfLife 2.5-3.3 hours
gptkbp:excretion renal
gptkbp:firstSynthesized 1990s
https://www.w3.org/2000/01/rdf-schema#label Valacyclovir
gptkbp:KEGGID D02366
gptkbp:legalStatus prescription only
gptkbp:marketedAs GlaxoSmithKline
gptkbp:mechanismOfAction inhibits viral DNA polymerase
gptkbp:metabolism gptkb:acyclovir
gptkbp:molecularWeight 324.33 g/mol
gptkbp:pregnancyCategory B (US)
B1 (Australia)
gptkbp:prescribes immunocompromised patients
HIV patients (for herpes suppression)
prevention of cytomegalovirus infection in transplant patients
gptkbp:prodrugOf gptkb:acyclovir
gptkbp:proteinBinding 13-18%
gptkbp:PubChem_CID gptkb:CHEMBL1435
135398744
DB00577
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
vomiting
abdominal pain
dizziness
headache
rash
gptkbp:UNII 61OQ44D3UN
gptkbp:usedFor gptkb:chickenpox
shingles
genital herpes
herpes simplex virus infection
herpes zoster
varicella zoster virus infection
cold sores
gptkbp:bfsParent gptkb:Antiviral
gptkbp:bfsLayer 6