|
gptkbp:instanceOf
|
gptkb:chemical_compound
|
|
gptkbp:approvalYear
|
1976
|
|
gptkbp:ATCCode
|
gptkb:C07AB03
|
|
gptkbp:bioavailability
|
50% (oral)
|
|
gptkbp:CASNumber
|
gptkb:29122-68-7
|
|
gptkbp:color
|
white (solid)
|
|
gptkbp:contraindication
|
asthma
heart block
severe bradycardia
|
|
gptkbp:drugClass
|
beta blocker
beta-adrenergic antagonist
|
|
gptkbp:eliminationHalfLife
|
6-7 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:hasHydrogenBondAcceptorCount
|
4
|
|
gptkbp:hasHydrogenBondDonorCount
|
3
|
|
gptkbp:hasInChIKey
|
METKIMKYRPQLGS-UHFFFAOYSA-N
|
|
gptkbp:hasLogP
|
0.16
|
|
gptkbp:hasMolecularFormula
|
C14H22N2O3
|
|
gptkbp:haspKa
|
9.6
|
|
gptkbp:hasReceptorAffinity
|
selective for beta-1 adrenergic receptor
|
|
gptkbp:hasRotatableBonds
|
7
|
|
gptkbp:hasSMILES
|
CC(C)NCC(COC1=CC=CC=C1OCC(=O)N)O
|
|
gptkbp:hasTPSA
|
74.25 Ų
|
|
gptkbp:hasUNII
|
50VV3VW0TI
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CHEMBL1435
|
|
gptkbp:indication
|
gptkb:arrhythmia
myocardial infarction
hypertension
angina pectoris
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:manufacturer
|
gptkb:AstraZeneca
|
|
gptkbp:meltingPoint
|
152-155°C
|
|
gptkbp:MeSH_ID
|
gptkb:D010559
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
266.34
|
|
gptkbp:name
|
gptkb:Atenolol
|
|
gptkbp:originatedIn
|
synthetic
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
2162
CHEBI:2269
DB00335
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
fatigue
bradycardia
cold extremities
|
|
gptkbp:solubility
|
water soluble
|
|
gptkbp:status
|
approved
|
|
gptkbp:synonym
|
gptkb:Atenololum
gptkb:Tenormin
|
|
gptkbp:target
|
beta-1 adrenergic receptor
|
|
gptkbp:therapeuticArea
|
cardiovascular system
|
|
gptkbp:bfsParent
|
gptkb:Valacyclovir
|
|
gptkbp:bfsLayer
|
7
|