|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
Synaptobrevin-2
SYB2
|
|
gptkbp:associatedWith
|
synaptic transmission
neurotransmitter release
|
|
gptkbp:biologicalProcess
|
exocytosis
vesicle-mediated transport
regulation of synaptic plasticity
synaptic vesicle fusion
neurotransmitter secretion
vesicle docking and fusion
|
|
gptkbp:discoveredBy
|
gptkb:Richard_H._Scheller
|
|
gptkbp:encodes
|
VAMP2 protein
|
|
gptkbp:Entrez_Gene_ID
|
6844
|
|
gptkbp:expressedIn
|
brain
neurons
|
|
gptkbp:firstDescribed
|
1990
|
|
gptkbp:fullName
|
gptkb:Vesicle-associated_membrane_protein_2
|
|
gptkbp:function
|
SNARE binding
involved in synaptic vesicle exocytosis
mediates vesicle fusion
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
12647
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
VAMP2 gene
|
|
gptkbp:interactsWith
|
gptkb:SNAP-25
gptkb:syntaxin-1A
synaptophysin
|
|
gptkbp:length
|
3 exons
116 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
17p13.1
|
|
gptkbp:location
|
gptkb:synaptic_vesicle
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
sleep disorders
neurodevelopmental disorders
|
|
gptkbp:OMIM
|
185881
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Vamp2
|
|
gptkbp:pathway
|
gptkb:synaptic_vesicle_cycle
neurotransmitter release cycle
|
|
gptkbp:product
|
single transmembrane domain
VAMP2 protein
|
|
gptkbp:proteinFamily
|
gptkb:SNARE_family
|
|
gptkbp:subcellularLocation
|
synaptic vesicle membrane
|
|
gptkbp:UniProtID
|
gptkb:P63027
|
|
gptkbp:bfsParent
|
gptkb:VAMP2
gptkb:synaptobrevin
|
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gptkbp:bfsLayer
|
7
|