Triosephosphate isomerase

URI: https://gptkb.org/entity/Triosephosphate_isomerase
GPTKB entity
Statements (28)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activeSiteResidue glutamate
histidine
gptkbp:associatedWith gptkb:triosephosphate_isomerase_deficiency
gptkbp:biologicalProcess isomerase activity
gptkbp:catalyzes interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate
gptkbp:cofactor none required
gptkbp:discoveredBy gptkb:Luis_Leloir
gptkbp:EC_number 5.3.1.1
gptkbp:enzymeClassification gptkb:isomerase
gptkbp:foundIn gptkb:gluconeogenesis_pathway
gptkb:glycolysis_pathway
gptkbp:gene gptkb:TPI1
gptkbp:gene_location_(human) gptkb:chromosome_12p13
https://www.w3.org/2000/01/rdf-schema#label Triosephosphate isomerase
gptkbp:inhibitedBy phosphoglycolohydroxamate
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight ~27 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkb:Bacteria
gptkbp:PDB gptkb:1TIM
gptkbp:proteinFamily TIM barrel fold
gptkbp:requires energy production
gptkbp:structure homodimer
gptkbp:systematicName D-glyceraldehyde-3-phosphate ketol-isomerase
gptkbp:UniProtID gptkb:P60174
gptkbp:bfsParent gptkb:Structure_313T
gptkbp:bfsLayer 7