Transcriptional corepressor SIN3A

URI: https://gptkb.org/entity/Transcriptional_corepressor_SIN3A
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:Paired_amphipathic_helix_protein_Sin3a
SIN3 transcription regulator family member A
gptkbp:associatedWith gptkb:Witteveen-Kolk_syndrome
intellectual disability
gptkbp:domain HID domain
PAH domain
Sin3_corepress domain
gptkbp:Entrez_Gene_ID ENSG00000171735
gptkbp:firstDescribed 1996
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of gene expression
chromatin remodeling
transcriptional corepressor
gptkbp:gene gptkb:SIN3A
gptkbp:GO_term GO:0005634 (nucleus)
GO:0003714 (transcription corepressor activity)
https://www.w3.org/2000/01/rdf-schema#label Transcriptional corepressor SIN3A
gptkbp:interactsWith gptkb:FOXO1
gptkb:REST
gptkb:MAD1
gptkb:MECP2
histone deacetylase 1 (HDAC1)
histone deacetylase 2 (HDAC2)
gptkbp:length 1273
gptkbp:locatedOnChromosome 15q24.2
gptkbp:location gptkb:nucleus
gptkbp:molecularWeight 145 kDa
gptkbp:orthologInMouse Sin3a
gptkbp:part_of_complex gptkb:Sin3/HDAC_complex
gptkbp:PDB 6HD8
gptkbp:RefSeq NM_015260
gptkbp:regulates apoptosis
DNA repair
metabolism
cell cycle
neuronal development
gptkbp:reviewedBy gptkb:Nature_Reviews_Molecular_Cell_Biology
gptkb:Journal_of_Biological_Chemistry
Cell
gptkbp:UniProtID Q96ST3
gptkbp:bfsParent gptkb:SIN3A
gptkbp:bfsLayer 8