|
gptkbp:instanceOf
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gptkb:protein
transcription factor
|
|
gptkbp:alternativeName
|
gptkb:SP2_transcription_factor
gptkb:Specificity_protein_2
|
|
gptkbp:domain
|
zinc finger domain
|
|
gptkbp:encodedBy
|
gptkb:SP2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000163220
6667
|
|
gptkbp:expressedIn
|
various tissues
|
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gptkbp:family
|
gptkb:Sp/KLF_family
|
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gptkbp:function
|
transcriptional activation
regulation of gene expression
DNA binding
|
|
gptkbp:HGNC_ID
|
11205
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Transcription factor Sp2
|
|
gptkbp:interactsWith
|
GC-rich promoter elements
other Sp family proteins
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
17q21.3
|
|
gptkbp:molecularWeight
|
~74 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus_Sp2
gptkb:Rattus_norvegicus_Sp2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
cell cycle
|
|
gptkbp:significance
|
implicated in cancer
implicated in neurodevelopmental disorders
|
|
gptkbp:UniProtID
|
Q02086
|
|
gptkbp:bfsParent
|
gptkb:SP2
|
|
gptkbp:bfsLayer
|
6
|