Transcription Activator-Like Effector Nucleases
GPTKB entity
Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genome editing technology
|
| gptkbp:abbreviation |
gptkb:TALENs
|
| gptkbp:alternativeTo |
gptkb:CRISPR-Cas9
Zinc Finger Nucleases |
| gptkbp:bindingDomainOrigin |
gptkb:Xanthomonas_bacteria
|
| gptkbp:bindingDomainType |
Transcription Activator-Like Effector (TALE)
|
| gptkbp:composedOf |
FokI nuclease domain
DNA-binding domain |
| gptkbp:developedBy |
researchers at Iowa State University
|
| gptkbp:enables |
gene correction
gene insertion targeted gene knockout |
| gptkbp:firstDescribed |
2010
|
| https://www.w3.org/2000/01/rdf-schema#label |
Transcription Activator-Like Effector Nucleases
|
| gptkbp:mechanismOfAction |
double-strand DNA breaks
|
| gptkbp:patent |
gptkb:Cellectis
gptkb:Sangamo_BioSciences |
| gptkbp:recognitionCode |
repeat-variable diresidue (RVD)
|
| gptkbp:relatedTo |
gptkb:CRISPR
Zinc Finger Nucleases |
| gptkbp:requires |
custom protein engineering
|
| gptkbp:target |
specific DNA sequences
|
| gptkbp:usedFor |
genome editing
|
| gptkbp:usedIn |
gptkb:agricultural_machinery
biomedical research functional genomics human cell genome editing animal genome engineering plant genome engineering |
| gptkbp:bfsParent |
gptkb:TALENs
|
| gptkbp:bfsLayer |
7
|