|
gptkbp:instanceOf
|
gptkb:antibiotic
tetracycline antibiotic
|
|
gptkbp:affiliatedWith
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
gptkbp:approvalYear
|
1971
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
J01AA08
|
|
gptkbp:brand
|
gptkb:Solodyn
gptkb:Minocin
Dynacin
|
|
gptkbp:CASNumber
|
10118-90-8
|
|
gptkbp:chemicalFormula
|
C23H27N3O7
|
|
gptkbp:contraindication
|
pregnancy
children under 8
liver impairment
|
|
gptkbp:discoveredBy
|
gptkb:Lederle_Laboratories
|
|
gptkbp:drugClass
|
tetracyclines
|
|
gptkbp:eliminationHalfLife
|
11-26 hours
|
|
gptkbp:excretion
|
gptkb:kidney
feces
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
minocycline
|
|
gptkbp:interactsWith
|
gptkb:warfarin
retinoids
antacids
oral contraceptives
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits bacterial protein synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:riskFactor
|
gptkb:pseudotumor_cerebri
hepatotoxicity
Esophageal cancer
drug-induced lupus
hypersensitivity reactions
tooth discoloration
autoimmune reactions
superinfection
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
dizziness
photosensitivity
skin discoloration
vestibular toxicity
|
|
gptkbp:usedFor
|
acne
rheumatoid arthritis
bacterial infections
rosacea
|
|
gptkbp:bfsParent
|
gptkb:Tetracyclines
|
|
gptkbp:bfsLayer
|
5
|