Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cell surface receptor |
| gptkbp:alternativeName |
thyrotropin receptor
TSHR |
| gptkbp:associatedWith |
Graves' disease
hypothyroidism hyperthyroidism |
| gptkbp:discoveredBy |
J. E. Rall
|
| gptkbp:domain |
extracellular domain
intracellular domain transmembrane domain |
| gptkbp:EC_number |
7.1.1.2
|
| gptkbp:encodedBy |
TSHR gene
|
| gptkbp:expressedIn |
thyroid follicular cells
|
| gptkbp:firstDescribed |
1980s
|
| gptkbp:function |
binds thyroid-stimulating hormone
regulates thyroid hormone production |
| gptkbp:HGNC_ID |
HGNC:12384
|
| https://www.w3.org/2000/01/rdf-schema#label |
TSH receptor
|
| gptkbp:ligand |
gptkb:thyroid-stimulating_hormone
|
| gptkbp:locatedIn |
thyroid gland
|
| gptkbp:locatedOnChromosome |
chromosome 14q31
|
| gptkbp:memberOf |
gptkb:G_protein-coupled_receptor
|
| gptkbp:mutationAssociatedWith |
congenital hypothyroidism
toxic thyroid adenoma |
| gptkbp:OMIM |
603372
|
| gptkbp:structure |
seven transmembrane domains
|
| gptkbp:target |
autoantibodies in Graves' disease
|
| gptkbp:type |
activates adenylate cyclase
increases cAMP |
| gptkbp:UniProtID |
P16473
|
| gptkbp:bfsParent |
gptkb:thyroid-stimulating_hormone_(TSH)
|
| gptkbp:bfsLayer |
6
|