|
gptkbp:instanceOf
|
gptkb:protein
gptkb:cell_surface_receptor
|
|
gptkbp:alternativeName
|
thyrotropin receptor
TSHR
|
|
gptkbp:associatedWith
|
Graves' disease
hypothyroidism
hyperthyroidism
|
|
gptkbp:discoveredBy
|
J. E. Rall
|
|
gptkbp:domain
|
extracellular domain
intracellular domain
transmembrane domain
|
|
gptkbp:EC_number
|
7.1.1.2
|
|
gptkbp:encodedBy
|
TSHR gene
|
|
gptkbp:expressedIn
|
thyroid follicular cells
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:function
|
binds thyroid-stimulating hormone
regulates thyroid hormone production
|
|
gptkbp:HGNC_ID
|
HGNC:12384
|
|
gptkbp:ligand
|
gptkb:thyroid-stimulating_hormone
|
|
gptkbp:locatedIn
|
thyroid gland
|
|
gptkbp:locatedOnChromosome
|
chromosome 14q31
|
|
gptkbp:memberOf
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:mutationAssociatedWith
|
congenital hypothyroidism
toxic thyroid adenoma
|
|
gptkbp:OMIM
|
603372
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:target
|
autoantibodies in Graves' disease
|
|
gptkbp:type
|
activates adenylate cyclase
increases cAMP
|
|
gptkbp:UniProtID
|
P16473
|
|
gptkbp:bfsParent
|
gptkb:thyroid-stimulating_hormone_(TSH)
gptkb:thyroid-stimulating_hormone
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TSH receptor
|