TALENs (Transcription Activator-Like Effector Nucleases)
GPTKB entity
Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genome editing technology
artificial restriction enzyme |
| gptkbp:advantage |
high specificity
|
| gptkbp:application |
disease modeling
functional genomics gene therapy research |
| gptkbp:component |
gptkb:FokI_endonuclease
transcription activator-like effector (TALE) proteins |
| gptkbp:composedOf |
FokI nuclease domain
DNA-binding domain |
| gptkbp:developedBy |
gptkb:Joung_Lab
gptkb:Voytas_Lab |
| gptkbp:firstDescribed |
2010
|
| https://www.w3.org/2000/01/rdf-schema#label |
TALENs (Transcription Activator-Like Effector Nucleases)
|
| gptkbp:limitation |
delivery challenges
labor-intensive design |
| gptkbp:mechanismOfAction |
induces double-strand breaks in DNA
|
| gptkbp:patent |
gptkb:Cellectis
gptkb:Sangamo_BioSciences |
| gptkbp:recognitionCode |
TALE repeats recognize single DNA bases
|
| gptkbp:relatedTo |
gptkb:CRISPR-Cas9
gptkb:Zinc_finger_nucleases |
| gptkbp:targetRecognition |
customizable DNA sequence
|
| gptkbp:usedFor |
genome editing
gene knockout gene insertion gene modification |
| gptkbp:usedIn |
animal genome editing
plant genome editing human cell genome editing |
| gptkbp:bfsParent |
gptkb:TALE_proteins
|
| gptkbp:bfsLayer |
7
|