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gptkbp:instanceOf
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gptkb:enzyme
|
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gptkbp:abbreviation
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gptkb:SOD1
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gptkbp:alternativeName
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gptkb:Cu,Zn_superoxide_dismutase
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gptkbp:associatedWith
|
amyotrophic lateral sclerosis
|
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gptkbp:biologicalProcess
|
antioxidant activity
response to oxidative stress
superoxide dismutase activity
metal ion binding
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gptkbp:cellularComponent
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gptkb:cytoplasm
|
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gptkbp:cofactor
|
copper
zinc
|
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gptkbp:discoveredBy
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gptkb:Irwin_Fridovich
|
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gptkbp:discoveredIn
|
1969
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gptkbp:EC_number
|
1.15.1.1
|
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gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000142168
gptkb:SOD1
|
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gptkbp:expressedIn
|
many tissues
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gptkbp:foundIn
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gptkb:cytoplasm
|
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gptkbp:function
|
catalyzes dismutation of superoxide radicals
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gptkbp:gene
|
gptkb:SOD1
gptkb:SOD1_gene
|
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gptkbp:HGNC_ID
|
11179
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|
https://www.w3.org/2000/01/rdf-schema#label
|
Superoxide dismutase 1
|
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gptkbp:inhibitedBy
|
increased oxidative stress
|
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gptkbp:locatedOnChromosome
|
gptkb:21q22.11
|
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gptkbp:location
|
cytosol
|
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gptkbp:molecularWeight
|
~16 kDa
|
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gptkbp:mutationAssociatedWith
|
nonsense
deletion
insertion
missense
linked to familial ALS
|
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gptkbp:OMIM
|
147450
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologInMouse
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gptkb:Sod1
|
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gptkbp:orthologInYeast
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gptkb:SOD1
|
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gptkbp:pathway
|
detoxification of reactive oxygen species
|
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gptkbp:PDB
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gptkb:1SPD
|
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gptkbp:product
|
hydrogen peroxide
oxygen
|
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gptkbp:proteinFamily
|
gptkb:Cu/Zn_superoxide_dismutase_family
|
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gptkbp:RefSeq
|
gptkb:NP_000445.1
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gptkbp:significance
|
biomarker for oxidative stress
mutations cause familial ALS
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gptkbp:structure
|
homodimer
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gptkbp:substrate
|
gptkb:superoxide_anion
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gptkbp:subunit
|
homodimer
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gptkbp:UniProtID
|
gptkb:P00441
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gptkbp:bfsParent
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gptkb:SOD-1
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gptkbp:bfsLayer
|
6
|