|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:antibiotic
sulfonamide
|
|
gptkbp:ATCCode
|
J01EC01
|
|
gptkbp:bioavailability
|
>90%
|
|
gptkbp:CASNumber
|
723-46-6
|
|
gptkbp:category
|
WHO Essential Medicines
|
|
gptkbp:combines
|
trimethoprim
|
|
gptkbp:contraindication
|
severe kidney disease
severe liver disease
sulfa allergy
|
|
gptkbp:developedBy
|
gptkb:Roche
|
|
gptkbp:discoveredBy
|
gptkb:Roche
|
|
gptkbp:discoveredIn
|
1961
|
|
gptkbp:eliminationHalfLife
|
10 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C10H11N3O3S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sulfamethoxazole
|
|
gptkbp:IUPACName
|
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
|
|
gptkbp:KEGGID
|
D00470
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits dihydropteroate synthase
|
|
gptkbp:meltingPoint
|
169°C
|
|
gptkbp:MeSH_ID
|
D013436
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:proteinBinding
|
70%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL29
5329
DB01015
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
allergic reaction
rash
photosensitivity
|
|
gptkbp:solubility
|
610 mg/L at 37°C
|
|
gptkbp:synonym
|
gptkb:SMX
Gantanol
Sulfamethoxazolum
|
|
gptkbp:UNII
|
9ZA14QY0F1
|
|
gptkbp:usedFor
|
gptkb:pneumocystis_pneumonia
bronchitis
urinary tract infections
bacterial infections
traveler's diarrhea
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|