|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:ATP_synthase
|
|
gptkbp:component
|
oxidative phosphorylation
electron transport chain
|
|
gptkbp:determines
|
X-ray crystallography
cryo-electron microscopy
|
|
gptkbp:discoveredBy
|
gptkb:Paul_Boyer
gptkb:John_E._Walker
|
|
gptkbp:dysregulationAssociatedWith
|
neurodegenerative diseases
mitochondrial diseases
metabolic disorders
|
|
gptkbp:EC_number
|
7.1.2.2
|
|
gptkbp:foundIn
|
gptkb:Bacteria
eukaryotes
|
|
gptkbp:function
|
synthesizes ATP from ADP and inorganic phosphate
|
|
gptkbp:gene
|
gptkb:ATP5F1D
gptkb:ATP5F1E
gptkb:ATP5F1A
gptkb:ATP5F1B
gptkb:ATP5F1C
gptkb:ATP5MC1
gptkb:ATP5MC2
gptkb:ATP5MC3
gptkb:ATP5ME
gptkb:ATP5MF
gptkb:ATP5MG
gptkb:ATP5PB
gptkb:ATP5PD
gptkb:ATP5PF
|
|
gptkbp:GO_term
|
GO:0005753 (mitochondrial proton-transporting ATP synthase complex)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Structure V
|
|
gptkbp:inhibitedBy
|
gptkb:venturicidin
gptkb:oligomycin
|
|
gptkbp:KEGGID
|
hsa00190 (Oxidative phosphorylation)
|
|
gptkbp:location
|
inner mitochondrial membrane
|
|
gptkbp:mechanismOfAction
|
rotary catalysis
|
|
gptkbp:molecularWeight
|
~600 kDa
|
|
gptkbp:NobelPrizeYear
|
1997 Chemistry
|
|
gptkbp:notableDriver
|
proton-motive force
|
|
gptkbp:OMIM
|
606153
|
|
gptkbp:orthologIn
|
gptkb:chloroplast_ATP_synthase
bacterial ATP synthase
|
|
gptkbp:powerSource
|
proton gradient
|
|
gptkbp:protonTranslocation
|
across inner mitochondrial membrane
|
|
gptkbp:requires
|
cellular energy production
|
|
gptkbp:subunit
|
gptkb:F1_sector
Fo sector
|
|
gptkbp:subunitCount
|
16 (in mammals)
8 (in bacteria)
|
|
gptkbp:UniProtID
|
P06576 (ATP5F1A)
|
|
gptkbp:bfsParent
|
gptkb:Hormiguero
|
|
gptkbp:bfsLayer
|
6
|